STIMULATORY EFFECTS OF 5-HYDROXYTRYPTAMINE ON FLUID SECRETION AND TRANSMURAL POTENTIAL DIFFERENCE IN RAT SMALL-INTESTINE ARE MEDIATED BY DIFFERENT RECEPTOR SUBTYPES

被引：29

作者：

BEUBLER, E

COUPAR, IM

HARDCASTLE, J

HARDCASTLE, PT

机构：

[1] UNIV SHEFFIELD,DEPT BIOMED SCI,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

[2] INST EXPTL & KLIN PHARMAKOL,A-8010 GRAZ,AUSTRIA

[3] VICTORIAN COLL PHARM,SCH PHARMACOL,PARKVILLE,VIC 3052,AUSTRALIA

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1990年 / 42卷 / 01期

关键词：

D O I：

10.1111/j.2042-7158.1990.tb05345.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Abstract— The rise in transmural potential difference (PD) and the fluid secretion induced by 5‐hydroxytryptamine (5‐HT) were measured in rat small intestine in‐vivo. Both cisapride and ketanserin abolished the 5‐HT‐induced rise in systolic blood pressure mediated by 5‐HT2 receptors. Cisapride inhibited the 5‐HT‐induced increases in the transintestinal PD, but over the same dose range it had no effect on the fluid secretion induced by 5‐HT. In contrast, ketanserin caused a dose‐dependent reduction in 5‐HT‐induced fluid secretion at doses that failed to influence the rise in PD. It is concluded that different receptors are responsible for the effects of 5‐HT on fluid secretion and electrical activity in the rat small intestine. 1990 Royal Pharmaceutical Society of Great Britain

引用

页码：35 / 39

页数：5