RIFAMPIN FOR THERAPY OF EXPERIMENTAL PNEUMOCOCCAL MENINGITIS IN RABBITS

被引：41

作者：

NAU, R

KAYE, K

SACHDEVA, M

SANDE, ER

TAUBER, MG

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT MED,DIV INFECT DIS,SAN FRANCISCO,CA 94143

[2] SAN FRANCISCO GEN HOSP,INFECT DIS LAB,SAN FRANCISCO,CA 94110

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 05期

关键词：

D O I：

10.1128/AAC.38.5.1186

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Rifampin at a maximally effective dose was less active than ceftriaxone (both drugs at 10 mg/kg of body weight.h) in a rabbit model of pneumococcal meningitis (Delta log(10) CFU/ml.h, -0.40 +/- 0.13 versus -0.77 +/- 0.18; P < 0.01). The bactericidal activity of rifampin decreased at concentrations in cerebrospinal fluid greater than those that are clinically achievable, and use of rifampin in combination with ofloxacin had no synergistic or additive effect.

引用

页码：1186 / 1189

页数：4

共 23 条

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