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ACTIVITY MECHANISM OF 1-NITROSO-3-NITRO-1-METHYLGUANIDINE DURING MUTATION INDUCTION .2. REACTION PRODUCTS OF I-NITROSO-3-NITRO-1-METHYLGUANIDINE WITH NUCLEIC ACID BASES NUCLEOSIDES NUCLEOSIDE PHOSPHATES AND HOMOPOLYRIBONUCLEIC ACIDS

被引：13
作者：
LINGENS, F
RAU, J
SUSSMUTH, R
机构：
[1] Institut für Mikrobiologie und Molekularbiologie der Universität Hohenheim, Stuttgart-Hohenheim
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG PART B-CHEMIE BIOCHEMIE BIOPHYSIK BIOLOGIE UND VERWANDTEN GEBIETE | 1968年 / B 23卷 / 12期
关键词：
D O I：
10.1515/znb-1968-1202
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
L-Nitroso-3-nitro-l-methyl-guanidine (NNMG) (at pH 5,5 resp. 6,0) methylates and deaminates the bases of nucleic acids. We treated nucleic bases, nucleosides, nucleoside phosphates and homopolyribonucleic acids with NNM G and we found the following methyl derivates of adenine: 1-methyladenine, 3-methyladenine and N6-methyladenine: of guanine: 7-methylguanine and of cytosine: 1-methylcytosine and 3-methylcytosine. Moreover bases of the nucleic acids were deaminated: adenine to hypoxanthine and guanine to xanthine. © 1968, Walter de Gruyter. All rights reserved.
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页码：1565 / &
相关论文
共 25 条
[1]   ACTION OF NITROUS ACID ON ALIPHATIC AMINES [J].
AUSTIN, AT .
NATURE, 1960, 188 (4756) :1086-1088
[2]  
CHANDRA P, 1967, Z NATURFORSCH PT B, VB 22, P512
[3]   REACTION OF N-METHYL-N'-NITRO-N-NITROSOGUANIDINE WITH DEOXYRIBONUCLEIC ACID [J].
CRADDOCK, VM .
BIOCHEMICAL JOURNAL, 1968, 106 (04) :921-&
[4]  
DECKER CH, 1965, J AMER CHEM SOC, V87, P4027
[5]   PREVENTION BY CYSTEAMINE OF INHIBITORY EFFECT OF CARCINOGENIC N-NITROSODIALKYLAMINES ON INCORPORATION OF AMINO-ACIDS IN RAT LIVER [J].
EMMELOT, P ;
KRIEK, E ;
MIZRAHI, IJ .
NATURE, 1962, 193 (4821) :1158-&
[6]   THE REACTION OF AMINES WITH N-METHYL-N-NITROSO-N'-NITROGUANIDINE [J].
HENRY, RA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1950, 72 (07) :3287-3289
[7]   METHYLATION OF DEOXYRIBONUCLEIC ACID BY DIAZOMETHANE [J].
KRIEK, E ;
EMMELOT, P .
BIOCHIMICA ET BIOPHYSICA ACTA, 1964, 91 (01) :59-&
[8]   METHYLATION OF DNA BY N-METHYL-N-NITROSOURETHANE AND N-METHYL-N-NITROSO-N'-NITROGUANIDINE [J].
LAWLEY, PD .
NATURE, 1968, 218 (5141) :580-&
[9]   MECHANISM OF ALKYLATION OF NUCLEIC ACIDS BY NITROSODIMETHYLAMINE [J].
LIJINSKY, W ;
LOO, J ;
ROSS, AE .
NATURE, 1968, 218 (5147) :1174-&
[10]   UBER DIE MUTAGENE WIRKUNG VON1-NITROSO-3-NITRO-1-METHYL-GUANIDIN (NNMG) AUF SACCHAROMYCES CEREVISIAE [J].
LINGENS, F ;
OLTMANNS, O .
ZEITSCHRIFT FUR NATURFORSCHUNG PART B-CHEMIE BIOCHEMIE BIOPHYSIK BIOLOGIE UND VERWANDTEN GEBIETE, 1966, B 21 (07) :660-&
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