ACTIVITY MECHANISM OF 1-NITROSO-3-NITRO-1-METHYLGUANIDINE DURING MUTATION INDUCTION .2. REACTION PRODUCTS OF I-NITROSO-3-NITRO-1-METHYLGUANIDINE WITH NUCLEIC ACID BASES NUCLEOSIDES NUCLEOSIDE PHOSPHATES AND HOMOPOLYRIBONUCLEIC ACIDS

被引：13

作者：

LINGENS, F

RAU, J

SUSSMUTH, R

机构：

[1] Institut für Mikrobiologie und Molekularbiologie der Universität Hohenheim, Stuttgart-Hohenheim

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG PART B-CHEMIE BIOCHEMIE BIOPHYSIK BIOLOGIE UND VERWANDTEN GEBIETE | 1968年 / B 23卷 / 12期

关键词：

D O I：

10.1515/znb-1968-1202

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

L-Nitroso-3-nitro-l-methyl-guanidine (NNMG) (at pH 5,5 resp. 6,0) methylates and deaminates the bases of nucleic acids. We treated nucleic bases, nucleosides, nucleoside phosphates and homopolyribonucleic acids with NNM G and we found the following methyl derivates of adenine: 1-methyladenine, 3-methyladenine and N6-methyladenine: of guanine: 7-methylguanine and of cytosine: 1-methylcytosine and 3-methylcytosine. Moreover bases of the nucleic acids were deaminated: adenine to hypoxanthine and guanine to xanthine. © 1968, Walter de Gruyter. All rights reserved.

引用

页码：1565 / &

共 25 条

[11]

LINGENS F, 1967, NATURWISSENSCHAFTEN, V54, P492

[12]

LINGENS F, UNPUBLISHED

[13] A NEW CHEMICAL MUTAGEN FOR BACTERIA, 1-METHYL-3-NITRO-1-NITROSOGUANIDINE [J].