EFFECTS OF ADRIAMYCIN AND X-RAYS ON EUOXIC AND HYPOXIC EMT-6 CELLS INVITRO

被引:28
作者
HARRIS, JW
SHRIEVE, DC
机构
[1] Department of Radiation Oncology, University of California, San Francisco
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1979年 / 5卷 / 08期
关键词
Adriamycin; Hypoxic cells; X-rays;
D O I
10.1016/0360-3016(79)90647-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
EMT-6 mouse tumor cells were grown in vitro and exposed to Adriamycin (and six other drugs) under conditions of euoxia, acute hypoxia or chronic hypoxia. Although the sensitivity of these cells (assayed as colony formation) was somewhat different than other EMT-6 cell lines and varied considerably from drug to drug, there was no difference between euoxic and hypoxic conditions. Moreover, Adriamycin did not consistently affect the radiation survival of these EMT-6 cells and specifically did not modify the shoulder region of the X-ray survival curve. © 1979.
引用
收藏
页码:1245 / 1248
页数:4
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