ABSOLUTE CONCENTRATIONS OF METABOLITES IN THE ADULT HUMAN BRAIN INVIVO - QUANTIFICATION OF LOCALIZED PROTON MR SPECTRA

被引:523
作者
MICHAELIS, T [1 ]
MERBOLDT, KD [1 ]
BRUHN, H [1 ]
HANICKE, W [1 ]
FRAHM, J [1 ]
机构
[1] MAX PLANCK INST BIOPHYS CHEM,POSTFACH 2841,W-3400 GOTTINGEN,GERMANY
关键词
BRAIN; METABOLISM; WHITE MATTER; GLUCOSE; MAGNETIC RESONANCE (MR); SPECTROSCOPY;
D O I
10.1148/radiology.187.1.8451417
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
In vivo concentrations of cerebral metabolites were obtained by means of 52 single-voxel, localized proton magnetic resonance (MR) spectroscopic examinations of different regions of the brain performed in 26 healthy adults aged 21-32 years. The study was performed at 2.0 T with use of a circularly polarized head coil to ensure homogeneous radio-frequency excitation and signal reception. Proton MR spectra were obtained in the stimulated-echo acquisition mode under fully relaxed conditions (repetition time greater-than-or-equal-to 6,000 msec) and at short echo times (20 msec) to minimize corrections due to T1 and T2 attenuation and depict the spectra of metabolites with strongly coupled resonances. Absolute concentrations were obtained by means of calibration of resonance signal areas with those of pertinent metabolite solutions from separate studies and correction for coil loading and partial volume effects (eg, with perfused capillary networks and cerebrospinal fluid). The results provide a quantitative basis for studies of both normal human neurochemistry in vivo and metabolic alterations in diseases of the brain.
引用
收藏
页码:219 / 227
页数:9
相关论文
共 77 条
  • [71] TALLAN HH, 1957, J BIOL CHEM, V224, P41
  • [72] THULBORN KR, 1983, J MAGN RESON, V55, P357, DOI 10.1016/0022-2364(83)90118-X
  • [73] Tofts P S, 1988, NMR Biomed, V1, P1, DOI 10.1002/nbm.1940010103
  • [74] INVIVO C-13 NUCLEAR MAGNETIC-RESONANCE INVESTIGATIONS OF CHOLINE METABOLISM IN RABBIT BRAIN
    TUNGGAL, B
    HOFMANN, K
    STOFFEL, W
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1990, 13 (01) : 90 - 102
  • [75] AGE-DEPENDENT CHANGES IN LOCALIZED PROTON AND PHOSPHORUS MR SPECTROSCOPY OF THE BRAIN
    VANDERKNAAP, MS
    VANDERGROND, J
    VANRIJEN, PC
    FABER, JAJ
    VALK, J
    WILLEMSE, K
    [J]. RADIOLOGY, 1990, 176 (02) : 509 - 515
  • [76] VEECH RL, 1979, J BIOL CHEM, V254, P6538
  • [77] QUANTITATIVE REGIONAL DETERMINATION OF MORPHOMETRIC INDEXES OF THE TOTAL AND PERFUSED CAPILLARY NETWORK IN THE RAT-BRAIN
    WEISS, HR
    BUCHWEITZ, E
    MURTHA, TJ
    AULETTA, M
    [J]. CIRCULATION RESEARCH, 1982, 51 (04) : 494 - 503