UNIQUE LOCALIZATION OF FUCOSYL GM1 IN RABBIT SPINAL-CORD AND PERIPHERAL-NERVE - IMMUNOHISTOCHEMICAL STUDY USING MONOCLONAL ANTI-FUCOSYL GM1 ANTIBODY CRD73-6

被引：11

作者：

KUSUNOKI, S ^{[1
]}

CHIBA, A ^{[1
]}

SHIMIZU, T ^{[1
]}

KANAZAWA, I ^{[1
]}

机构：

[1] TEIKYO UNIV,DEPT NEUROL,TOKYO 173,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM | 1994年 / 1214卷 / 01期

关键词：

GANGLIOSIDE; DORSAL ROOT GANGLION; SPINAL CORD; PERIPHERAL NERVE; MOTOR NEURON; DEVELOPMENT; (RABBIT);

D O I：

10.1016/0005-2760(94)90005-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We generated a murine monoclonal antibody (CRD73-6) for ganglioside fucosyl GM1 using a homogenate of rabbit dorsal root ganglia as an immunogen. CRD73-6 immunostained a subset of neurons and the satellite cells surrounding them in rabbit dorsal root ganglia, unmyelinated fibers in the dorsal root, and dorsal horn of the spinal cord. After the tissue sections had been treated with acetone, CRD73-6 also immunostained large neurons and the perineuronal area around them in the venteral horn, and axons and myelin of the small myelinated fibers in the dorsal root. Unique localization of fucosyl GM1 implicates its possible role in cell adhesion and recognition in the nervous system.

引用

页码：27 / 31

页数：5

共 17 条

[1] TUMOR-CELL KILLING BY MABS AGAINST FUCOSYL GM1, A GANGLIOSIDE ANTIGEN ASSOCIATED WITH SMALL-CELL LUNG-CARCINOMA [J].