INDUCTION OF CD40 IN PROMYELOCYTIC HL-60 CELLS CULTURED WITH RETINOIC ACID AND/OR VARIOUS CYTOKINES

被引:4
作者
SHINAGAWA, T [1 ]
NUNOI, H [1 ]
NONOYAMA, S [1 ]
KANEGASAKI, S [1 ]
机构
[1] UNIV TOKYO,INST MED SCI,MINATO KU,TOKYO 108,JAPAN
关键词
CD40; CD40L; GRANULOCYTE; HL-60 CELL LINE; MONOCYTE;
D O I
10.1093/oxfordjournals.jbchem.a124941
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The antigenic protein CD40 on the surface of B lymphocytes plays an important role in their proliferation, immunoglobulin class switching, and rescue from apoptosis in the germinal center through interaction with T lymphocytes expressing CD40 ligand, The protein is also found on the cell surface of other antigen-presenting cells such as monocytes, dendritic cells, and thymic epithelium cells, but its presence in other myeloid cells has not been reported. We show here that CD40 protein is induced in promyelocytic HL60 cells, when cultured with retinoic acid, a vitamin that converts them to granulocyte-like cells. The cultured cells also expressed CD15, a marker for granulocytes, and cytochrome b(558) an essential component of the superoxide-generating system in phagocytes, on their surface. No detectable amount of mRNA for CD40 was found in naive HL60 cells, whereas a large amount of the message was induced in the cells cultured with the vitamin. Although CD40 expression was enhanced when the cells were further cultured with GM-CSF or IFN-gamma, expression of CD14, a marker for monocytes, was also enhanced, HL60 cells, therefore, express CD40 protein during differentiation not only toward monocytes but also toward granulocytes, at least transiently.
引用
收藏
页码:534 / 540
页数:7
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