SKELETAL-MUSCLE FIBER COMPOSITION IS RELATED TO ADIPOSITY AND IN-VITRO GLUCOSE-TRANSPORT RATE IN HUMANS

被引:261
作者
HICKEY, MS
CAREY, JO
AZEVEDO, JL
HOUMARD, JA
PORIES, WJ
ISRAEL, RG
DOHM, GL
机构
[1] E CAROLINA UNIV, SCH MED, DEPT SURG, GREENVILLE, NC 27858 USA
[2] E CAROLINA UNIV, SCH MED, DEPT BIOCHEM, GREENVILLE, NC 27858 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 1995年 / 268卷 / 03期
关键词
INSULIN RESISTANCE; MORBID OBESITY;
D O I
10.1152/ajpendo.1995.268.3.E453
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The purpose of this study was to determine if a relationship exists among skeletal muscle fiber composition, adiposity, and in vitro muscle glucose transport rate in humans. Rectus abdominus muscle was obtained during elective abdominal surgery from nonobese control(n = 12), obese (n = 12), and obese non-insulin-dependent diabetes mellitus (NIDDM) patients (n = 10). The obese NIDDM group had a significantly lower percentage of type I muscle fibers (32.2 +/- 1.9%) than the obese group (40.4 +/- 2.7%), and both obese groups were significantly lower than the control group (50.0 +/- 2.6%). Insulin-stimulated glucose transport, determined on 28 subjects, was significantly lower in both the obese (3.83 +/- 0.48 nmol . min(-1). mg(-1)) and NIDDM (3.93 +/- 1.0 nmol . min(-1). mg(-1)) groups vs. the control group (7.35 +/- 1.50 nmol . min(-1). mg(-1)). Body mass index (BMI) was inversely correlated to percent type I fibers (r = -0.50, P < 0.01) and to the insulin-stimulated glucose transport rate (r = -0.53, P < 0.01), The percentage of type I muscle fibers was related to the insulin-stimulated glucose transport rate (r = 0.57, P < 0.01), although this relationship was not significant after adjusting for BMI. Although these data do not support an independent relationship between fiber type and insulin action in obesity, a reduced skeletal muscle type I fiber population may be one component of a multifactorial process involved in the development of insulin resistance.
引用
收藏
页码:E453 / E457
页数:5
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