INFLUENCE OF LEAVING GROUP ON RATE OF PHOSPHORYLATION

被引：30

作者：

HUDSON, RF

GREENHAL.R

机构：

[1] University Chemical Laboratory, University of Kent at Canterbury, Canterbury, Kent

来源：

JOURNAL OF THE CHEMICAL SOCIETY B-PHYSICAL ORGANIC | 1969年 / 04期

关键词：

D O I：

10.1039/j29690000325

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rates of alkaline hydrolysis and reaction with n-butylamine of a series of phosphorylating agents of general formula (Pr1O)2POX, [X = F, Cl, CN, and (Pr1O)2P:O] are measured. The different rate orders are explained in terms of the relative leaving-group tendencies of X, H2O, and BuNH2 in transient penta-covalent intermediates. The general-base catalysis of the hydrolysis of the fluoridate by n-butylamine is discussed.

引用

页码：325 / &

共 25 条

[21] CHEMISTRY AND STEREOCHEMISTRY OF FLUOROPHOSPHORANES
SCHMUTZLER, R
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1965, 4 (06) : 496 - +
[22] SYRIN YK, 1950, STRUCTURE MOLECULES, P261
[23] THE PREPARATION OF TETRAETHYL PYROPHOSPHATE AND OTHER TETRAALKYL PYROPHOSPHATES
TOY, ADF
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1948, 70 (11) : 3882 - 3886
[24] TUNG TS, 1965, HUA HSUEH HSUEH PAO, V31, P199
[25] THE MECHANISMS OF HYDROGEN PEROXIDE REACTIONS .2. A COMPARISON OF THE REACTIVITY OF HYDROXYL ION AND HYDROPEROXIDE ION TOWARD BENZONITRILE
WIBERG, KB
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1955, 77 (09) : 2519 - 2521

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