ACUTE AXONAL DYSTROPHY CAUSED BY FLUOROCITRATE - ROLE OF MITOCHONDRIAL SWELLING

被引：26

作者：

KOENIG, H

机构：

[1] Veterans Administration Research Hospital, Department of Neurology and Psychiatry, Northwestern University Medical School, Chicago

来源：

SCIENCE | 1969年 / 164卷 / 3877期

关键词：

D O I：

10.1126/science.164.3877.310

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fluorocitrate, a Krebs cycle inhibitor, induces neurons to rapidly expel multitudinous lysosomes, mitochondria, and other cytoplasmic constituents into their axons. After convulsive seizures commence, spectacular axonal balloons develop owing to obstruction of axonal flow by log jams" of extruded organelles. A swelling of neuronal mitochondria is apparently responsible for the disgorgement of cytoplasmic material into axons."

引用

页码：310 / +

页数：1

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