Effect of Macrophage Activation on Plasma Disposition of Niosomal H-3-Methotrexate in Sarcoma-180 Bearing Mice

被引：11

作者：

Chandraprakash, K. S. ^{[1
]}

Udupa, N. ^{[1
]}

Umadevi, P. ^{[2
]}

Pillai, G. K. ^{[3
]}

机构：

[1] Kasturba Med Coll, Coll Pharmaceut Sci, Manipal 576119, Dk Karnataka, India

[2] KMC, Dept Radiobiol, Manipal 576119, Dk Karnataka, India

[3] Univ Sci & Technol, Coll Pharm, Irbid, Jordan

来源：

JOURNAL OF DRUG TARGETING | 1993年 / 1卷 / 02期

关键词：

methotrexate niosome; MDP-gelatin conjugate; macrophage activation; turnover regression; pharmacokinetics;

D O I：

10.3109/10611869308996070

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Methotrexate niosomes were formed by reverse phase evaporation technique using sorbitan monostearate (Span 60) surfactant. The pharmacokinetic parameters of methotrexate (MTX) after macrophage activation via muramyl dipeptide gelatin conjugate were studied and the results compared with those obtained after free MTX and MTX niosomes without macrophage activation. In mice MTX concentrations and tumour regression were higher after macrophage activation.

引用

页码：143 / 145

页数：3

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