SNAR REACTIONS OF BENZALDIMINES - A CONCISE SYNTHESIS OF SUBSTITUTED PHENANTHRIDINES

被引：13

作者：

REUTER, DC

FLIPPIN, LA

MCINTOSH, J

CAROON, JM

HAMMAKER, J

机构：

[1] Institute of Organic Chemistry, Syntex Discovery Research, Palo Alto, CA 94304

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 28期

关键词：

NUCLEOPHILIC AROMATIC SUBSTITUTION; AROMATIC ALDIMINES; ORGANOLITHIUM REAGENTS;

D O I：

10.1016/S0040-4039(00)73277-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Halogenated benzaldimines react with dilithiated N-Boc-aniline derivatives to yield biaryl imines via a SNAr reaction. Mild hydroysis of this imine then allows cyclization to the substituted phenanthridine. Extension of this reaction to a variety of N-Boc-anilines and imines was explored.

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页码：4899 / 4902

页数：4

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