COLLAGEN AND COLLAGEN-DERIVED FRAGMENTS ARE CHEMOTACTIC FOR TUMOR-CELLS

被引：127

作者：

MUNDY, GR

DEMARTINO, S

ROWE, DW

机构：

[1] UNIV CONNECTICUT, CTR HLTH, DEPT MED, FARMINGTON, CT 06032 USA

[2] UNIV CONNECTICUT, CTR HLTH, DEPT PEDIAT, FARMINGTON, CT 06032 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1981年 / 68卷 / 04期

关键词：

D O I：

10.1172/JCI110334

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Organs that are rich in collagen such as liver, lungs and bone are frequently sites of tumor cell metastasis. Cultured tumor cells of human and rat origin migrated unidirectionally in response to collagen in vitro. Synthetic di- and tri-peptides that contained amino acid sequences found frequently in the collagen helix caused similar effects. These results are consistent with the hypothesis that collagen or collagen fragments released during connective tissue remodeling may be important in tumor cell metastasis.

引用

收藏

页码：1102 / 1105

页数：4

相关论文

共 14 条

[1] BREAST TUMOR-CELL LINES FROM PLEURAL EFFUSIONS [J].

CAILLEAU, R ;

YOUNG, R ;

OLIVE, M ;

REEVES, WJ .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1974, 53 (03) :661-674

[2] COLLAGEN POLYMORPHISM - CHARACTERIZATION OF MOLECULES WITH CHAIN COMPOSITION [ALPHA-1(III)]3 IN HUMAN TISSUES [J].

CHUNG, E ;

MILLER, EJ .

SCIENCE, 1974, 183 (4130) :1200-1201

[3] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].

LAEMMLI, UK .

NATURE, 1970, 227 (5259) :680-+

[4]

ORR FW, 1980, AM J PATHOL, V99, P43

[5]

ORR W, 1978, AM J PATHOL, V93, P405

[6] CHEMOTACTIC RESPONSES OF TUMOR-CELLS TO PRODUCTS OF RESORBING BONE [J].

ORR, W ;

VARANI, J ;

GONDEK, MD ;

WARD, PA ;

MUNDY, GR .

SCIENCE, 1979, 203 (4376) :176-179

[7] COLLAGEN-INDUCED AND COLLAGEN PEPTIDE-INDUCED CHEMOTAXIS OF HUMAN-BLOOD MONOCYTES [J].

POSTLETHWAITE, AE ;

KANG, AH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1976, 143 (06) :1299-1307

[8] CHEMOTACTIC ATTRACTION OF HUMAN FIBROBLASTS TO TYPE-I, TYPE-2, AND TYPE-3 COLLAGENS AND COLLAGEN-DERIVED PEPTIDES [J].

POSTLETHWAITE, AE ;

SEYER, JM ;

KANG, AH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (02) :871-875

[9] UNIQUE COMPLEMENT DERIVED CHEMOTACTIC FACTOR FOR TUMOR-CELLS [J].

ROMUALDEZ, AG ;

WARD, PA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (10) :4128-4132

[10]

ROMUALDEZ AG, 1976, J IMMUNOL, V117, P1762