PROTEIN ADSORPTION ON POLYMERIC BIOMATERIALS .2. ADSORPTION-KINETICS

被引：101

作者：

YOUNG, BR ^{[1
]}

PITT, WG ^{[1
]}

COOPER, SL ^{[1
]}

机构：

[1] UNIV WISCONSIN, DEPT CHEM ENGN, MADISON, WI 53706 USA

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 1988年 / 125卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Antibodies - Biomaterials - Surfaces - Polymers - Surfaces - Polyvinyl Chloride - Surfaces - Solutions - Concentration;

D O I：

10.1016/0021-9797(88)90073-2

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The adsorption kinetics of seven human proteins on four polymer surfaces were studied under a wide range of solution concentrations. The proteins were albumin (HSA), transferrin (TF), α2-macroglobulin (α2-M), three immunoglobulin G monoclonal antibodies (IgG), and fibrinogen (FGN). The polymers were a polyurethaneurea (PEUU), plasticized polyvinyl chloride (PVC), silicone rubber (SR), and polyethylene (PE). The results showed that, in general, the intrinsic adsorption rates and the amount adsorbed increased in the order TF, α2-M, HSA, IgGs, and FGN. With the exception of HSA, this is the same order in which the tendency toward precipitation by ethanol increased.

引用

页码：246 / 260

页数：15

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