CORRELATION OF SERUM INTERLEUKIN-6 LEVELS WITH JOINT INVOLVEMENT AND THROMBOCYTOSIS IN SYSTEMIC JUVENILE RHEUMATOID-ARTHRITIS

被引：286

作者：

DEBENEDETTI, F ^{[1
]}

MASSA, M ^{[1
]}

ROBBIONI, P ^{[1
]}

RAVELLI, A ^{[1
]}

BURGIO, GR ^{[1
]}

MARTINI, A ^{[1
]}

机构：

[1] UNIV PAVIA,INST RIC & CURA CARATTERE SCI,POLICLIN S MATTEO,I-27100 PAVIA,ITALY

来源：

ARTHRITIS AND RHEUMATISM | 1991年 / 34卷 / 09期

关键词：

D O I：

10.1002/art.1780340912

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We measured interleukin-6 (IL-6) levels in 70 serum samples obtained from 25 patients with systemic-onset juvenile rheumatoid arthritis (JRA), using the hybridoma cell line B9. Patients with systemic-onset JRA had significantly elevated serum IL-6 levels during active disease (mean +/- SD 92.1 +/- 75.1 hybridoma growth factor units/ml; P < 0.00001 versus healthy age-matched controls), but not during remission. Serum IL-6 levels correlated with the extent and severity of joint involvement (P < 0.001) and with platelet counts (P < 0.05). Our data suggest that IL-6 plays a significant role in the pathogenesis of systemic-onset JRA.

引用

页码：1158 / 1163

页数：6