A ROLE FOR CD8+ LYMPHOCYTES-T IN THE PATHOGENESIS OF AIDS

被引：11

作者：

ARANDAANZALDO, A

机构：

[1] Laboratoire d'Immunobiologie, Faculté de Médecine Paris V, 75270 Paris Cedex 06

来源：

RESEARCH IN IMMUNOLOGY | 1991年 / 142卷 / 07期

关键词：

AIDS; HIV; REPLICATION; LYMPHOCYTE-T; IMMUNOSUPPRESSION; CLONAL ANERGY; GRAFT VS; HOST DISEASE; EXPERIMENTAL IMMUNODEFICIENCY; POSITION PAPER;

D O I：

10.1016/0923-2494(91)90099-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Experimental and clinical evidence is presented which supports the hypothesis that CD8+ T lymphocytes aimed at suppressing HIV replication in infected CD4+ T cells may have an important role in the pathogenesis of AIDS by directly causing a decrease in CD4+ T lymphocyte numbers. Possible models to test this hypothesis are discussed.

引用

页码：541 / 550

页数：10

共 64 条

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