AN IMPROVED PROCEDURE FOR THE SYNTHESIS AND USE OF [RUCL2(BINAP)]2.NET3 - DEPENDENCE OF THE RU(II)-BINAP CATALYZED ASYMMETRIC HYDROGENATION OF BETA-KETO-ESTERS ON TRACE AMOUNTS OF ACID

被引：106

作者：

KING, SA

THOMPSON, AS

KING, AO

VERHOEVEN, TR

机构：

[1] Department of Process Research, Merck Research Laboratories, Rahway, New Jersey 07065

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 25期

关键词：

D O I：

10.1021/jo00051a002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric hydrogenation of beta-keto esters using 0.02-0.05 mol % Ru(II)-BINAP-derived catalyst can be conducted in a stardard Parr shaker apparatus at 40-degrees-C and 30 psi of hydrogen in the presence of 0.1 mol % of a strong acid.

引用

页码：6689 / 6691

页数：3