THE SKIN AS A TARGET ORGAN FOR THE INVESTIGATION OF ANTIALLERGIC DRUGS - COMPARISON BETWEEN CETIRIZINE AND TERFENADINE

被引：10

作者：

RIHOUX, JP

GHYS, L

MUHLETHALER, K

WUTHRICH, B

机构：

[1] UCB s.a., Pharmaceutical Sector, B1420 Braine-l'Alleud, Chemin du Foriest

来源：

DERMATOLOGY | 1992年 / 184卷 / 02期

关键词：

CETIRIZINE; TERFENADINE; HISTAMINE; ANTIGEN; CUTANEOUS REACTIVITY;

D O I：

10.1159/000247515

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Two double-blind clinical pharmacology studies were performed in atopics in order to compare the inhibitory effects of cetirizine (CTZ) 2 HCl and terfenadine (TER) on histamine and antigen-induced skin reactions. In the first study, the subjects took single intakes of CTZ 10 mg and TER 60 mg. In the second study, they took CTZ 10 mg once a day and TER 60 mg b.i.d. for 3 weeks. CTZ was more effective than TER in inhibiting histamine skin reactivity. CTZ and TER were equally effective in inhibiting antigen-induced reactions. There was no tachyphylaxis, either for CTZ or for TER.

引用

收藏

页码：111 / 115

页数：5

相关论文

共 31 条

[11] COMPARATIVE TRIAL OF 2 NON-SEDATIVE H-1 ANTIHISTAMINES, TERFENADINE AND ASTEMIZOLE, FOR HAY-FEVER [J].

HOWARTH, PH ;

HOLGATE, ST .

THORAX, 1984, 39 (09) :668-672

[12] INHIBITORY ACTIVITY OF TERFENADINE ON HISTAMINE-INDUCED SKIN WHEALS IN MAN [J].

HUTHER, KJ ;

RENFTLE, G ;

BARRAUD, N ;

BURKE, JT ;

KOCHWESER, J .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1977, 12 (03) :195-199

[13] INHIBITING EFFECT OF CETIRIZINE ON HISTAMINE-INDUCED AND 48/80-INDUCED WHEALS AND FLARES, EXPERIMENTAL DERMOGRAPHISM, AND COLD-INDUCED URTICARIA [J].

JUHLIN, L ;

DEVOS, C ;

RIHOUX, JP .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1987, 80 (04) :599-602

[14] EFFECT OF LONG-TERM TREATMENT WITH INHALED CORTICOSTEROIDS AND BETA-AGONISTS ON THE BRONCHIAL RESPONSIVENESS IN CHILDREN WITH ASTHMA [J].

KERREBIJN, KF ;

VANESSENZANDVLIET, EEM ;

NEIJENS, HJ .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1987, 79 (04) :653-659

[15] EFFECTS OF ANTIHISTAMINES ON ISOLATED RAT PERITONEAL MAST-CELLS AND ON MODEL MEMBRANE SYSTEMS [J].

LAU, HYA ;

PEARCE, FL .

AGENTS AND ACTIONS, 1990, 29 (3-4) :151-161

[16]

LOWE DA, 1980, PROG RESPIR RES, V14, P134

[17]

MICHEL L, 1990, ANN ALLERGY, V65, P512

[18] THE EFFECT OF AZELASTINE AND SOME OTHER ANTIASTHMATIC AND ANTIALLERGIC DRUGS ON CALMODULIN AND PROTEIN KINASE-C [J].

MIDDLETON, E ;

FERRIOLA, P ;

DRZEWIECKI, G ;

SOFIA, RD .

AGENTS AND ACTIONS, 1989, 28 (1-2) :9-15

[19] ATTENUATION OF CUTANEOUS REACTIVITY TO HISTAMINE BY CETIRIZINE AND DEXCHLORPHENIRAMINE [J].

MULLER, FO ;

BOTHA, JJD ;

VANDYK, M ;

LUUS, HG ;

GROENEWOUD, G .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1988, 35 (03) :319-321

[20]

NABE M, 1989, American Review of Respiratory Disease, V139, pA63

← 1 2 3 4 →