SYNTHETIC STUDIES ON THE COMPOUNDS RELATED TO NEOCARZINOSTATIN CHROMOPHORE .3. NOVEL SYNTHESIS OF A CHIRAL CYCLIC DIENEDIYNE SYSTEM

被引：29

作者：

NAKATANI, K ^{[1
]}

ARAI, K ^{[1
]}

TERASHIMA, S ^{[1
]}

机构：

[1] SAGAMI CHEM RES CTR,NISHI OHNUMA,SAGAMIHARA,KANAGAWA 229,JAPAN

来源：

TETRAHEDRON | 1993年 / 49卷 / 09期

关键词：

NEOCARZINOSTATIN CHROMOPHORE; CYCLIC DIENEDIYNE; D-XYLOSE; EPOXIDE; PD-CATALYZED COUPLING;

D O I：

10.1016/S0040-4020(01)80546-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel synthesis of the chiral 10-membered dienediynes (2 and 3) related to neocarzinostatin chromophore was accomplished by utilizing cyclization of an epoxy acetylene as a key step. The epoxy acetylene was prepared from the (Z)-dienediyne diol which could be obtained by coupling reaction of the (Z)-enol triflates (5) with the optically active acetylene diol (25) derived from D-xylose.

引用

页码：1901 / 1912

页数：12

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