A STRUCTURAL BASIS FOR TRANSPHOSPHORYLATION OF NUCLEOTIDES WITH HYDROXYAPATITE

被引:22
作者
TAVES, DR
REEDY, RC
机构
[1] Department of Radiation Biology and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, 14620, New York
来源
CALCIFIED TISSUE RESEARCH | 1969年 / 3卷 / 03期
关键词
Adenosine triphosphate; Hydroxyapatite; Nucleotides; Pyrophosphate; Transphosphorylation;
D O I
10.1007/BF02058670
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The basis for transphosphorylation between nucleotides and hydroxyapatite (HA) has been explored. Using a recently-proposed model for the surface of HA and the structure of 2- and 3-membered polyphosphates, a reasonable atomic explanation can be shown for this reaction. Transphosphorylation has been found to result in a pyrophosphate on HA which is distinctive from pyrophosphate absorbed onto HA from solution. The models suggest that this distinction is due to a different orientation of the pyrophosphate on the surface of the HA depending on the origin of the pyrophosphate. © 1969 Springer-Verlag.
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页码:284 / &
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