EFFECT OF CHOLESTEROL FEEDING ON PROTEIN-SYNTHESIS IN DIFFERENT REGIONS OF THE RABBIT ARTERIAL-WALL

被引：11

作者：

LANGNER, RO ^{[1
]}

GILLIGAN, JP ^{[1
]}

EHRHART, LA ^{[1
]}

机构：

[1] CLEVELAND CLIN EDUC FDN, CLEVELAND, OH 44106 USA

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 1979年 / 31卷 / 02期

关键词：

D O I：

10.1016/0014-4800(79)90032-7

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The site of increased collagen synthetic activity in aortas from rabbits fed a 2% cholesterol diet was investigated. After 70 days control and experimental animals were killed and the intima-media was carefully separated from the adventitia. Collagen and non-collagen protein synthetic rates were estimated following in vitro incorporation of [14C]proline. All of the cholesterol fed rabbits had lesions in the intima-media layer with little or no involvement of the adventitia. The intima-media demonstrated a greater increase in collagen and non-collagen protein synthetic activity than that observed in the media-adventitia. Since the greatest accumulation of cholesterol and cholesterol-esters occurred in the intima-media, the data suggests that the observed alteration in collagen and non-collagen protein synthesis represents a localized response to cholesterol deposition, rather than a generalized response occurring throughout the arterial wall. © 1979.

引用

页码：308 / 317

页数：10