PREPARATION OF AQUEOUS POLYMERIC NANODISPERSIONS BY A REVERSIBLE SALTING-OUT PROCESS - INFLUENCE OF PROCESS PARAMETERS ON PARTICLE-SIZE

被引：146

作者：

ALLEMANN, E ^{[1
]}

GURNY, R ^{[1
]}

DOELKER, E ^{[1
]}

机构：

[1] UNIV GENEVA,SCH PHARM,QUAI ERNEST ANSERMET 30,CH-1211 GENEVA 4,SWITZERLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 87卷 / 1-3期

关键词：

NANOPARTICLE; LATEX; POLYMERIC AQUEOUS DISPERSION; SALTING-OUT; METHACRYLIC ACID COPOLYMER; POLY(DL-LACTIC ACID); ETHYLCELLULOSE;

D O I：

10.1016/0378-5173(92)90249-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Polymeric nanoparticles were prepared as aqueous dispersions using an emulsion technique involving a salting-out process which avoids surfactants and chlorinated solvents. The preparation method consists of adding an electrolyte-saturated or a nonelectrolyte-saturated aqueous solution containing poly(vinyl alcohol) (PVAL) as a viscosity-increasing agent and stabilizer to an acetone solution of polymer under continuous stirring. The saturated aqueous solution prevents acetone from mixing with water by a salting-out process. After the preparation of an oil-in-water emulsion, water is added in a sufficient amount to allow complete diffusion of acetone into the aqueous phase, inducing the formation of nanospheres. Several manufacturing parameters were varied: stirring rate, internal/external phase ratio, concentration of polymer in the acetone phase, type of electrolyte, concentration and type of PVAL in the aqueous phase.

引用

页码：247 / 253

页数：7