BIODEGRADABLE HYDROGELS IN DRUG-DELIVERY

被引：319

作者：

KAMATH, KR ^{[1
]}

PARK, K ^{[1
]}

机构：

[1] PURDUE UNIV, SCH PHARM, W LAFAYETTE, IN 47907 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1993年 / 11卷 / 1-2期

关键词：

BIODEGRADATION; HYDROGELS; MECHANISMS OF DEGRADATION; CHEMICAL GELS; PHYSICAL GELS;

D O I：

10.1016/0169-409X(93)90027-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Biodegradable hydrogels have been exploited in the controlled drug delivery area due to various advantages. This review describes different types of biodegradable hydrogel systems, mechanisms and factors affecting their degradation, and their applications in drug delivery. Biodradable hydrogels were classified according to their method of preparation, degradable moiety in the systems, and the mode of biodegradation. In addition, this review describes the advantages and limitations of these systems pertaining to their potential for future applications.

引用

页码：59 / 84

页数：26

共 127 条

[1] COVALENT LINKAGE OF PROTEINS TO SURFACE-MODIFIED POLY(ORGANOPHOSPHAZENES) - IMMOBILIZATION OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE AND TRYPSIN [J].