A COMPARATIVE MOLECULAR-FIELD ANALYSIS DERIVED MODEL OF THE BINDING OF TAXOL(R) ANALOGS TO MICROTUBULES

被引：7

作者：

CZAPLINSKI, KHA ^{[1
]}

GRUNEWALD, GL ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT MED CHEM,LAWRENCE,KS 66045

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(00)80073-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We investigated a series of Taxol(R) (1, paclitaxel) analogues using a 3-D QSAR approach (CoMFA). Published and unpublished data for more than 50 compounds have been included in the analysis and the model has been used to predict the activity of other analogues. The model accurately describes known SARs and also has good predictive power.

引用

页码：2211 / 2216

页数：6

共 26 条

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