SCHISTOSOMA-JAPONICUM - AN ULTRAVIOLET-ATTENUATED CERCARIAL VACCINE APPLICABLE IN THE FIELD FOR WATER-BUFFALOS

Water buffaloes were vaccinated three times with 10,000 Schistosoma japonicum cercariae irradiated with ultraviolet (uv) light at a dose of 400 μW · min/cm2. The irradiation was performed with cheap, simple, and portable equipment in a rural area of Hubei Province (People's Republic of China). A challenge infection of 1000 untreated cercariae was given to six vaccinated and six naive control buffaloes, while two vaccinated animals were not challenged. The experiment was terminated 6 weeks after the challenge. Control animals had lost body weight and harbored a mean of 110 worms and 37 eggs per gram of liver. The vaccinated animals gained weight after the challenge and developed 89% resistance to infection with S. japonicum. Since schistosomiasis japonica is nowadays transmitted in China predominantly by domestic live-stock, a uv-attenuated cercarial vaccine for bovines may contribute to the control of this disease. © 1990.