POTENTIAL ANTIMALARIALS .6. 4'-CHLORO-3-(SUBSTITUTED AMINO)-METHYL-5-(7-TRIFLUOROMETHYLQUINOLIN-4-YLAMINO)BIPHENYL-2-OLS

被引：5

作者：

BARLIN, GB

JIRAVINYU, C

机构：

[1] Division of Neuroscience, John Curtin School of Medical Research, Australian National University, ACT, 2601

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1990年 / 43卷 / 07期

关键词：

D O I：

10.1071/CH9901301

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Syntheses are reported for 3-(t-butylamino)methyl-4′-chloro-5-(7″-trifluoromethylquinolin-4″- ylamino)biphenyl-2-ol (5b) and analogous Mannich bases from diethylamine, pyrrolidine, piperidine, 3- and 4-methylpiperidine, 4-benzylpiperidine and 4-benzylpiperazine via N- substituted 3-aminomethyl-4′-chloro-5-nitrobiphenyl-2-ols (9). These compounds have been prepared for evaluation as antimalarials. © 1990 ASEG.

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页码：1301 / 1307

页数：7

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