DNA POLYMERASE-DELTA - A 2ND EUKARYOTIC DNA REPLICASE

被引：45

作者：

DOWNEY, KM ^{[1
]}

TAN, CK ^{[1
]}

SO, AG ^{[1
]}

机构：

[1] UNIV MIAMI, SCH MED, DEPT BIOCHEM & MOLEC BIOL, MIAMI, FL 33101 USA

来源：

BIOESSAYS | 1990年 / 12卷 / 05期

关键词：

D O I：

10.1002/bies.950120507

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the past few years significant progress has been made in our understanding of the structure and function of the proteins involved in eukaryotic DNA replication. Data from several laboratories suggest that, in contrast to prokaryotic DNA replication, two distinct DNA polymerases are required for eukaryotic DNA replication, i.e. DNA polymerase delta for the synthesis of the leading strand and DNA polymerase alpha for the lagging strand. Several accessory proteins analogous to prokaryotic replication factors have been identified and some of these are specific for pol delta whereas others affect both DNA replicases. The replicases and their accessory proteins appear to be highly conserved in eukaryotes, as homologous proteins have been found in species ranging from humans to yeast. Copyright © 1990 Cambridge University Press

引用

页码：231 / 236

页数：6

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