SYNTHESIS OF C-14 AND H-3 LABELED 6-NITRO-7-SULFAMOYLBENZO[F]QUINOXALIN-2,3-DIONE

被引：4

作者：

FOGED, C

JACOBSEN, P

机构：

[1] Novo Nordisk Cns-Division, Måløv, DK‐2760, Novo Nordisk Park

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1992年 / 31卷 / 05期

关键词：

RADIOLABELED 6-NITRO-7-SULFAMOYLBENZO[F]QUINOXALIN-2,3-DIONE; NBQX; GLUTAMATE ANTAGONIST; AMPA;

D O I：

10.1002/jlcr.2580310505

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A C-14 labelled form of 6-nitro-7-sulfamoylbenzo[f]quinoxalin-2,3-dione [1] was synthesized in two steps from 1,2-diamino-5-sulfamoylnaphthalene [2] and 30 MCi C-14-oxalic acid. A total of 5.5 mCi was isolated as a yellow solid with a radiochemical purity > 99%. The specific activity was 99 mCi/mmol. A H-3 labelled form of [1] was synthesized in two steps from 10-bromo-7-sulfamoylbenzo-[f]quinoxalin-2-3-dione [4] and tritium gas. The product was isolated with a radiochemical purity of > 98% and a specific activity of 10 Ci/mmol.

引用

页码：365 / 373

页数：9

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