HEPATIC-MICROSOMAL MONOOXYGENASE ACTIVITY AND P450IA MESSENGER-RNA IN NORTH-SEA DAB LIMANDA-LIMANDA FROM CONTAMINATED SITES

被引：19

作者：

RENTON, KW ^{[1
]}

ADDISON, RF ^{[1
]}

机构：

[1] FISHERIES & OCEANS CANADA, BEDFORD INST OCEANOG, DARTMOUTH B2Y 4A2, NS, CANADA

来源：

MARINE ECOLOGY PROGRESS SERIES | 1992年 / 91卷 / 1-3期

关键词：

D O I：

10.3354/meps091065

中图分类号：

Q14 [生态学（生物生态学）];

学科分类号：

071012 ; 0713 ;

摘要：

Mature pre-spawning female dab Limanda Limanda were sampled during the Bremerhaven Workshop from stations in the southern North Sea along a transect heading approximately NW from the Elbe estuary (the 'German Bight Transect') and around an abandoned drilling site. Hepatic microsomal mono-oxygenase activity as shown by ethoxyresorufin O-deethylase (EROD) and cyanoethoxycoumarin O-deethylase (CN-ECOD) declined with increasing distance offshore, but rose slightly at the outermost station on the Dogger Bank. Microsomal P4501A1 mRNA, detected with a new synthetic oligonucleotide probe, followed the same trend. Activities of EROD and CN-ECOD and concentrations of P4501A1 mRNA were well correlated with the major chlorobiphenyl residues measured in dab and with hydrocarbon concentrations in sediments at these stations. Dab sampled from the drilling site had hepatic EROD and CN-ECOD activity and P4501A1 mRNA contents similar to those in fish from the offshore German Bight stations.

引用

页码：65 / 69

页数：5

共 24 条

[1] VARIATION OF HEPATIC ETHOXYCOUMARIN O-DE-ETHYLASE ACTIVITY WITH BODY-WEIGHT AND OTHER FACTORS IN BROOK TROUT (SALVELINUS-FONTINALIS) [J].

ADDISON, RF ;

WILLIS, DE .

CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES, 1982, 39 (06) :924-926

[2] MIXED-FUNCTION OXIDASE ENZYMES IN TROUT (SALVELINUS-FONTINALIS) LIVER - ABSENCE OF INDUCTION FOLLOWING FEEDING OF P,P'-DDT OR P,P'-DDE [J].

ADDISON, RF ;

ZINCK, ME ;

WILLIS, DE .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1977, 57 (01) :39-43

[3] HEPATIC-MICROSOMAL MONO-OXYGENASE ACTIVITY IN FLOUNDER PLATICHTHYS-FLESUS FROM POLLUTED SITES IN LANGESUNDFJORD AND FROM MESOCOSMS EXPERIMENTALLY DOSED WITH DIESEL OIL AND COPPER [J].

ADDISON, RF ;

EDWARDS, AJ .

MARINE ECOLOGY PROGRESS SERIES, 1988, 46 (1-3) :51-54

[4] EFFECTS OF UGILEC-141, A PCB SUBSTITUTE BASED ON TETRACHLOROBENZYLTOLUENES, ON HEPATIC MONO-OXYGENASE INDUCTION IN ESTUARINE FISH [J].

ADDISON, RF ;

HANSEN, PD ;

PLUTA, HJ ;

WILLIS, DE .

MARINE ENVIRONMENTAL RESEARCH, 1991, 31 (02) :137-144

[5]

ADDISON RF, 1986, 1505 FISH AQ SCI CAN

[6]

BURKE MD, 1974, DRUG METAB DISPOS, V2, P583

[7] THE CHEMISTRY PROGRAM [J].

COFINO, WP ;

SMEDES, F ;

DEJONG, SA ;

ABARNOU, A ;

BOON, JP ;

OOSTINGH, I ;

DAVIES, IM ;

KLUNGSOYR, J ;

WILHELMSEN, S ;

LAW, RJ ;

WHINNETT, JA ;

SCHMIDT, D ;

WILSON, S .

MARINE ECOLOGY PROGRESS SERIES, 1992, 91 (1-3) :47-56

[8]

DIXON WJ, 1983, BMDP STATISTICAL SOF

[9] EFFECTS OF CLOPHEN A50, 3-METHYLCHOLANTHRENE, "PREGNENOLONE-16-ALPHA-CARBONITRILE, AND PHENOBARBITAL ON THE HEPATIC-MICROSOMAL CYTOCHROME-P-450-DEPENDENT MONO-OXYGENASE SYSTEM IN RAINBOW-TROUT, SALMO-GAIRDNERI, OF DIFFERENT AGE AND SEX [J].

FORLIN, L .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1980, 54 (03) :420-430

[10] DETECTION OF CYTOCHROME-P450-1A1 IN NORTH-SEA DAB LIVER AND KIDNEY [J].

GOKSOYR, A ;

LARSEN, HE ;

BLOM, S ;

FORLIN, L .

MARINE ECOLOGY PROGRESS SERIES, 1992, 91 (1-3) :83-88

← 1 2 3 →