THE CHEMISTRY OF 1,1'-THIOBIS(2-CHLOROETHANE) (SULFUR MUSTARD) .2. THE SYNTHESIS OF SOME CONJUGATES WITH CYSTEINE, N-ACETYLCYSTEINE AND N-ACETYLCYSTEINE METHYL-ESTER

被引：18

作者：

BLACK, RM

BREWSTER, K

CLARKE, RJ

HARRISON, JM

机构：

[1] Chemical and Biological Defence Establishment, Porton Down, Salisbury, Wilts

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1992年 / 71卷 / 1-4期

关键词：

THIOBIS(2-CHLOROETHANE) AND CONJUGATES WITH CYSTEINE; N-ACETYLCYSTEINE AND N-ACETYLCYSTEINE METHYL ESTER; METABOLIC STUDIES;

D O I：

10.1080/10426509208034495

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The syntheses of a number of conjugates of 1,1'-thiobis(2-chloroethane) ("sulphur mustard") and its simple derivatives with cysteine, N-acetylcysteine and N-acetylcysteine methyl ester are described. These compounds were synthesised for use as reference compounds to support metabolite identification in metabolic studies and, in some cases, to provide standards for analytical procedures being developed for the retrospective confirmation of exposure to sulphur mustard.

引用

页码：49 / 58

页数：10