ATTENUATION OF SOME ALCOHOL-INDUCED MOOD CHANGES AND THE DESIRE TO DRINK BY 5-HT(3) RECEPTOR BLOCKADE - A PRELIMINARY-STUDY IN HEALTHY MALE-VOLUNTEERS

被引：82

作者：

JOHNSON, BA

CAMPLING, GM

GRIFFITHS, P

COWEN, PJ

机构：

[1] LITTLEMORE HOSP,MRC,CLIN PHARMACOL UNIT,OXFORD OX4 4XN,ENGLAND

[2] UNIV OXFORD,COMP SCI SERV,OXFORD,ENGLAND

来源：

PSYCHOPHARMACOLOGY | 1993年 / 112卷 / 01期

基金：

英国惠康基金;

关键词：

ALCOHOL; 5-HT(3) RECEPTORS; ONDANSETRON; REINFORCEMENT;

D O I：

10.1007/BF02247375

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the effect of the 5-HT3 receptor antagonist ondansetron (4 mg orally) on some of the psychological effects of a small dose of alcohol (580 ml of 3.6% alcohol content by volume of lager) in 16 healthy male volunteers using a double-blind placebo controlled, Latin Square cross-over design. Pretreatment with ondansetron significantly attenuated several of the subjective pleasurable effects of alcohol, and also decreased the subjective desire to drink. These findings are consistent with preclinical studies suggesting that the reinforcing properties of alcohol may be attenuated by 5-HT3 receptor blockade.

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页码：142 / 144

页数：3

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