学术探索
学术期刊
新闻热点
数据分析
智能评审

MDL 72222, A SELECTIVE 5-HT3 RECEPTOR ANTAGONIST, SUPPRESSES VOLUNTARY ETHANOL-CONSUMPTION IN ALCOHOL-PREFERRING RATS

被引：133
作者：
FADDA, F
GARAU, B
MARCHEI, F
COLOMBO, G
GESSA, GL
机构：
[1] UNIV CAGLIARI,BB BRODIE DEPT NEUROSCI,VIA PORCELL 4,I-09124 CAGLIARI,ITALY
[2] UNIV CAGLIARI,INST HUMAN PHYSIOL,I-09124 CAGLIARI,ITALY
来源：
ALCOHOL AND ALCOHOLISM | 1991年 / 26卷 / 02期
关键词：
D O I：
10.1093/oxfordjournals.alcalc.a045088
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
The effect of the selective 5-HT3 receptor antagonist MDL 72222 on voluntary ethanol consumption was examined in Sardinian ethanol-preferring (SP) rats in a free choice (10% ethanol and water) experiment. SP rats consumed 8.1 +/- 1.1 g/kg ethanol daily. MDL 72222 treatment (3.0, 5.0 and 7.0 mg/kg i.p. 3 times daily for 6 days) inhibited ethanol consumption during the 6 days of treatment by 25%, 50% and 75%, respectively, without modifying total fluid intake. We suggest that 5-HT3 receptor activation plays a permissive role in alcohol preference.
引用
收藏
页码：107 / 110
页数：4
相关论文
共 13 条
12