MDL 72222, A SELECTIVE 5-HT3 RECEPTOR ANTAGONIST, SUPPRESSES VOLUNTARY ETHANOL-CONSUMPTION IN ALCOHOL-PREFERRING RATS

被引：133

作者：

FADDA, F

GARAU, B

MARCHEI, F

COLOMBO, G

GESSA, GL

机构：

[1] UNIV CAGLIARI,BB BRODIE DEPT NEUROSCI,VIA PORCELL 4,I-09124 CAGLIARI,ITALY

[2] UNIV CAGLIARI,INST HUMAN PHYSIOL,I-09124 CAGLIARI,ITALY

来源：

ALCOHOL AND ALCOHOLISM | 1991年 / 26卷 / 02期

关键词：

D O I：

10.1093/oxfordjournals.alcalc.a045088

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

The effect of the selective 5-HT3 receptor antagonist MDL 72222 on voluntary ethanol consumption was examined in Sardinian ethanol-preferring (SP) rats in a free choice (10% ethanol and water) experiment. SP rats consumed 8.1 +/- 1.1 g/kg ethanol daily. MDL 72222 treatment (3.0, 5.0 and 7.0 mg/kg i.p. 3 times daily for 6 days) inhibited ethanol consumption during the 6 days of treatment by 25%, 50% and 75%, respectively, without modifying total fluid intake. We suggest that 5-HT3 receptor activation plays a permissive role in alcohol preference.

引用

页码：107 / 110

页数：4