HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY FOR ISOSORBIDE 5-MONONITRATE AND IMPURITIES OF INORGANIC NITRATES IN PHARMACEUTICALS

被引：4

作者：

AGBABA, D ^{[1
]}

JANJIC, V ^{[1
]}

ZIVANOVSTAKIC, D ^{[1
]}

VLADIMIROV, S ^{[1
]}

机构：

[1] QUAL CONTROL DEPT ZDRAVLJE, LESKOVAC, YUGOSLAVIA

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1994年 / 17卷 / 18期

关键词：

D O I：

10.1080/10826079408016167

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple and reliable high performance liquid chromatographic (HPLC) method for the quantification of isosorbide 5-mononitrate and inorganic nitrate impurity in raw material and dosage formulations has been developed and validated. The procedure which simultaneously resolves active organic nitrates : isosorbide 5-mononitrate, isosorbide 2-mononitrate and isosorbide 2.5-dinitrate, and main impurities (including related nitrate and acetate esters), may be used as a control of purity of raw material and dosage forms.

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页码：3983 / 3988

页数：6

相关论文

共 24 条

[1] NEW METHODS FOR THE ASSAY OF 5-ISOSORBIDE MONONITRATE AND ITS VALIDATION [J].

AZCONA, T ;

MARTINGONZALEZ, A ;

ZAMORANO, P ;

PASCUAL, C ;

GRAU, C ;

DEMIRASIERRA, MG .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1991, 9 (09) :725-729

[2]

BHALLA H L, 1984, Indian Drugs, V21, P158

[3] THIN-LAYER CHROMATOGRAPHY OF ISOSORBIDE DINITRATE, NITROGLYCERIN AND THEIR DEGRADATION PRODUCTS [J].

CARLSON, M ;

THOMPSON, RD .

JOURNAL OF CHROMATOGRAPHY, 1986, 368 (02) :472-475

[4] DETERMINATION OF ISOSORBIDE DINITRATE IN PHARMACEUTICAL PRODUCTS BY HPLC [J].

CARLSON, M ;

THOMPSON, RD ;

SNELL, RP .

JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1988, 26 (11) :574-578

[5] SEPARATION AND QUANTITATION OF POLYNITRATE ESTERS IN PHARMACEUTICAL PREPARATIONS BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

CAVAZZUTTI, C ;

GAGLIARDI, L ;

AMATO, A ;

GATTAVECCHIA, E ;

TONELLI, D .

JOURNAL OF CHROMATOGRAPHY, 1982, 244 (02) :391-395

[6] BIOTRANSFORMATION OF ISOSORBIDE DINITRATE IN DOGS AND HUMANS [J].

DIETZ, AJ .

BIOCHEMICAL PHARMACOLOGY, 1967, 16 (12) :2447-&

[7] PHOTOLYSIS OF NITRATE ESTERS .1. PHOTONITRATION OF DIPHENYLAMINE [J].

HAYWARD, LD ;

KITCHEN, RA ;

LIVINGST.DJ .

CANADIAN JOURNAL OF CHEMISTRY, 1962, 40 (03) :434-+

[8]

KAZANDZHIEVA P, 1987, FARMATSYA, V37, P1

[9] SIMULTANEOUS DETERMINATION OF ISOSORBIDE DINITRATE AND DIAZEPAM IN PHARMACEUTICAL PREPARATIONS BY HPLC WITH ELECTROCHEMICAL DETECTION [J].

KRAL, K ;

KAINZ, G .

FRESENIUS ZEITSCHRIFT FUR ANALYTISCHE CHEMIE, 1983, 316 (05) :497-500

[10]

LU WY, 1989, YANXUE XUEBEO, V24, P797