PURINE PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.7 AND 2.4.2.8) AND PURINE DENOVO SYNTHESIS ACTIVITY IN RAT TESTICULAR TISSUE AT DIFFERENT STAGES OF DEVELOPMENT, AND THEIR CORRELATION WITH THE CIRCULATING LEVELS OF GONADOTROPINS AND TESTOSTERONE, AND WITH STRUCTURAL-CHANGES

被引：11

作者：

ALLSOP, J ^{[1
]}

WATTS, RWE ^{[1
]}

机构：

[1] MRC, CLIN RES CTR, DIV INHERITED METAB DIS, WATFORD RD, HARROW HA1 3UJ, MIDDX, ENGLAND

来源：

DIFFERENTIATION | 1986年 / 32卷 / 02期

关键词：

D O I：

10.1111/j.1432-0436.1986.tb00566.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The overall activity of the purine de novo synthesis pathway and the activities of purine phosphoribosyltransferase in the rat testis were measured at different ages and were correlated with histological observations. Similar studies of the concentration of circulating gonadotrophins and testosterone were performed. The purine phosphoribosyltransferase activities were between two and three orders of magnitude greater than purine de novo synthesis. The peak activity of the purine de novo synthesis pathway coincided with the first appearance of meiosis in the spermatocytes immediately before the luteinising hormone (LH) level rose to its peak. The highest activity of the hypoxanthine phosphoribosyltransferase (HPRT; EC 2.4.2.8)-catalysed purine salvage pathway coincided with the first appearance of mature spermatozoa in the tubules just after the occurrence of peak levels of follicle-stimulating hormone (FSH). These findings are linked to the development of testicular atrophy in cases of severe HPRT deficiency in man.

引用

页码：144 / 147

页数：4

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