CLINICAL USEFULNESS OF CYFRA ASSAY IN DIAGNOSING LUNG-CANCER - MEASUREMENT OF SERUM CYTOKERATIN FRAGMENT

被引：47

作者：

SUGAMA, Y

KITAMURA, S

KAWAI, T

OHKUBO, A

HASEGAWA, S

KURIYAMA, T

KATO, H

FUKUOKA, M

OHKAWA, J

机构：

[1] JICHI MED SCH,DEPT CLIN PATHOL,JICHI,TOCHIGI 32904,JAPAN

[2] UNIV TOKYO,FAC MED,DEPT LAB MED,BUNKYO KU,TOKYO 113,JAPAN

[3] UNIV TSUKUBA,INST CLIN MED SCI,DEPT INTERNAL MED,TSUKUBA,IBARAKI 305,JAPAN

[4] CHIBA UNIV,SCH MED,DEPT CHEST MED,CHUO KU,CHIBA 280,JAPAN

[5] TOKYO MED COLL,DEPT SURG,SHINJUKU KU,TOKYO 160,JAPAN

[6] OSAKA CITY GEN HOSP,DEPT RESP MED & MED ONCOL,MIYAKOJIMA KU,OSAKA 534,JAPAN

[7] HYOGO MED CTR ADULTS,DEPT PATHOL,AKASHI,HYOGO 673,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1994年 / 85卷 / 11期

关键词：

TUMOR MARKER; CYTOKERATIN FRAGMENT; LUNG CANCER;

D O I：

10.1111/j.1349-7006.1994.tb02925.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We evaluated the diagnostic usefulness of measurement of the soluble cytokeratin 19 fragment, a new tumor marker, in 391 patients with lung cancer and in 424 patients with benign lung diseases. Serum concentrations of cytokeratin 19 fragment were measured by a sandwich ELISA (CYFRA). The cut-off value was defined as 3.5 ng/ml, which is associated with a specificity of 85% for benign lung diseases. CYFRA had a high sensitivity (57.5%) in all subjects with lung carcinoma, and had a higher sensitivity for squamous cell carcinoma (73.1%, n=141) than squamous cell carcinoma-related antigen (61.0%). CYFRA was associated with a relatively high sensitivity (42.1%) in early-stage squamous cell carcinoma (stage I, based on the classification of the Japan Lung Cancer Society), but the CYFRA titer was higher in advanced squamous cell carcinoma than in early stage squamous cell carcinoma. Our findings suggest that CYFRA is potentially useful for diagnosis and monitoring of. lung carcinoma, especially for squamous cell carcinoma.

引用

页码：1178 / 1184

页数：7