REGULATION OF ATRIAL AUTONOMIC RECEPTORS IN EXPERIMENTAL CYANOTIC HEART-DISEASE

被引:5
作者
DOSHI, R [1 ]
STRANDNESS, E [1 ]
BERNSTEIN, D [1 ]
机构
[1] STANFORD UNIV, DEPT PEDIAT, STANFORD, CA 94305 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1991年 / 261卷 / 04期
关键词
BETA-ADRENERGIC RECEPTOR; MUSCARINIC RECEPTOR; HYPOXIA;
D O I
10.1152/ajpheart.1991.261.4.H1135
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
During chronic hypoxemia, left ventricular beta-adrenergic receptor density is decreased and a dissociation occurs between increased chronotropic and decreased inotropic responses to chronically elevated sympathetic tone. To determine whether this dissociation was related to alterations in autonomic receptor populations in the right atrium, we studied right atrial cholinergic and beta-adrenergic receptors in chronically hypoxemic newborn lambs and in normoxemic controls. Heart rate response was determined by infusing isoproterenol at 0.1 or 0.5-mu-g.kg-1.min-1. Muscarinic receptors were quantified with [H-3]quinuclidinyl benzilate and beta-adrenergic receptors with [I-125]iodocyanopindolol. Competition with ICI 118,551 was used to determine beta-1- vs. beta-2-receptor subtypes. In the hypoxemic lambs, isoproterenol resulted in a lesser percentage increase in heart rate (hypoxemic, 46 +/- 6% vs. control, 89 +/- 17%, P < 0.05); however, because baseline heart rate was higher in the hypoxemic lambs (213 +/- 7 vs. 177 +/- 12 beats/min, P < 0.05), maximal heart rate responses were similar (310 +/- 7 vs. 326 +/- 6 beats/min, NS). There was no change in receptor density or affinity of either muscarinic or beta-adrenergic receptors and no change in the proportion of beta-1- vs. beta-2-receptor subtypes. Thus the dissociation between the chronotropic and inotropic responses to chronic hypoxemia may be in part secondary to a differential regulation of beta-adrenergic receptors between the left ventricle and the right atrium.
引用
收藏
页码:H1135 / H1140
页数:6
相关论文
共 35 条
[1]   DIFFERENTIAL REGULATION OF RIGHT AND LEFT-VENTRICULAR BETA-ADRENERGIC RECEPTORS IN NEWBORN LAMBS WITH EXPERIMENTAL CYANOTIC HEART-DISEASE [J].
BERNSTEIN, D ;
VOSS, E ;
HUANG, S ;
DOSHI, R ;
CRANE, C .
JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (01) :68-74
[2]   REDISTRIBUTION OF REGIONAL BLOOD-FLOW AND OXYGEN DELIVERY IN EXPERIMENTAL CYANOTIC HEART-DISEASE IN NEWBORN LAMBS [J].
BERNSTEIN, D ;
TEITEL, D ;
SIDI, D ;
HEYMANN, MA ;
RUDOLPH, AM .
PEDIATRIC RESEARCH, 1987, 22 (04) :389-393
[3]   CHRONIC BETA-ADRENOCEPTOR ANTAGONIST TREATMENT MODULATES HUMAN CARDIAC AND VASCULAR BETA-ADRENOCEPTOR DENSITY IN A SUBTYPE-SELECTIVE FASHION [J].
BRODDE, OE ;
MICHEL, MC ;
WANG, XL ;
ZERKOWSKI, HR .
JOURNAL OF HYPERTENSION, 1988, 6 :S497-S500
[4]   MYOCARDIAL BETA-ADRENOCEPTOR CHANGES IN HEART-FAILURE - CONCOMITANT REDUCTION IN BETA-1-ADRENOCEPTOR AND BETA-2-ADRENOCEPTOR FUNCTION RELATED TO THE DEGREE OF HEART-FAILURE IN PATIENTS WITH MITRAL-VALVE DISEASE [J].
BRODDE, OE ;
ZERKOWSKI, HR ;
DOETSCH, N ;
MOTOMURA, S ;
KHAMSSI, M ;
MICHEL, MC .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1989, 14 (02) :323-331
[5]   BETA-ADRENOCEPTOR REGULATION IN THE HUMAN-HEART - CAN IT BE MONITORED IN CIRCULATING LYMPHOCYTES [J].
BRODDE, OE ;
MICHEL, MC ;
GORDON, EP ;
SANDOVAL, A ;
GILBERT, EM ;
BRISTOW, MR .
EUROPEAN HEART JOURNAL, 1989, 10 :2-10
[7]  
COHEN-ARMON M, 1986, J BIOL CHEM, V261, P2498
[8]   ADRENERGIC SUPPORT OF CARDIAC FUNCTION DURING HYPOXIA IN NEWBORN LAMB [J].
DOWNING, SE ;
GARDNER, TH ;
ROCAMORA, JM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1969, 217 (03) :728-&
[9]  
FIELDS JZ, 1978, J BIOL CHEM, V253, P3251
[10]   ASSESSMENT OF THE BETA-ADRENERGIC-RECEPTOR PATHWAY IN THE INTACT FAILING HUMAN-HEART - PROGRESSIVE RECEPTOR DOWN-REGULATION AND SUBSENSITIVITY TO AGONIST RESPONSE [J].
FOWLER, MB ;
LASER, JA ;
HOPKINS, GL ;
MINOBE, W ;
BRISTOW, MR .
CIRCULATION, 1986, 74 (06) :1290-1302