INCORPORATION OF HOMOLOGOUS AND HETEROLOGOUS PROTEINS INTO THE ENVELOPE OF MOLONEY MURINE LEUKEMIA-VIRUS

被引:66
作者
SUOMALAINEN, M
GAROFF, H
机构
关键词
D O I
10.1128/JVI.68.8.4879-4889.1994
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The efficiencies with which homologous and heterologous proteins are incorporated into the envelope of Moloney murine leukemia virus (M-MuLV) have been analyzed by utilizing a heterologous, Semliki Forest virus-driven M-MuLV assembly system and quantitative pulse-chase assays. Homologous M-MuLV spike protein was found to be efficiently incorporated into extracellular virus particles when expressed at a relatively low density at the plasma membrane. In contrast, efficient incorporation of heterologous proteins (the spike complex of Semliki Forest virus and a cytoplasmically truncated mutant of the human transferrin receptor) was observed only when these proteins were expressed at high densities at the cell surface. These results imply that homologous and heterologous proteins are incorporated into the M-MuLV envelope via two distinct pathways.
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页码:4879 / 4889
页数:11
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