INTERLEUKIN-6 LEVELS IN THE PLASMA OF PATIENTS WITH LYMPHOMA

被引：16

作者：

YEE, C ^{[1
]}

SUTCLIFFE, S ^{[1
]}

MESSNER, HA ^{[1
]}

MINDEN, MD ^{[1
]}

机构：

[1] ONTARIO CANC INST, DEPT MED & BIORES, 500 SHERBOURNE ST, TORONTO M4X 1K9, ONTARIO, CANADA

来源：

LEUKEMIA & LYMPHOMA | 1992年 / 7卷 / 1-2期

关键词：

IL-6; PLASMA; LYMPHOMA;

D O I：

10.3109/10428199209053611

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have suggested a growth stimulatory role of lymphoma cells in culture by interleukin 6. To test the hypothesis that IL-6 may have a role in vivo, the plasma of lymphoma patients was assayed for the presence of IL-6 bioactivity. A significantly greater proportion of lymphoma patients had elevated IL-6 levels (23 of 40) compared to controls (3 of 35). In follow-up, eight of 15 patients with previously elevated levels returned with decreased or undetectable levels of IL-6 post radio- or chemotherapy. This response was seen primarily in those with intermediate or high grade lymphomas. In contrast no change in IL-6 levels was seen in patients with low grade lymphoma despite measurable reductions in tumor size in both groups. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：123 / 129

页数：7

共 37 条

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