NON-ADRENOCEPTOR [H-3] IDAZOXAN BINDING-SITES (I2-IMIDAZOLINE SITES) ARE INCREASED IN POSTMORTEM BRAIN FROM PATIENTS WITH ALZHEIMERS-DISEASE

被引：78

作者：

RUIZ, J

MARTIN, I

CALLADO, LF

MEANA, JJ

BARTUREN, F

GARCIASEVILLA, JA

机构：

[1] UNIV BASQUE COUNTRY, DEPT FARMACOL, EUSKAL HERRIKO UNIBERTSITATEA, E-48940 LEIOA, SPAIN

[2] UNIV BALEARIC ISL, DEPT FUNDAMENTAL BIOL & HLTH SCI, NEUROPHARMACOL LAB, PALMA DE MALLORCA, SPAIN

来源：

NEUROSCIENCE LETTERS | 1993年 / 160卷 / 01期

关键词：

I2-IMIDAZOLINE SITE; IMIDAZOLINE PREFERRING RECEPTORS; H-3]IDAZOXAN; ALZHEIMERS DISEASE; HUMAN BRAIN; GLIA; PI(2)-ADRENOCEPTORS;

D O I：

10.1016/0304-3940(93)90925-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The 12-imidazoline site (a non-adrenergic mitochondrial site for which a glial location has been proposed and that is associated with the B-form of the enzyme monoamine oxidase) was evaluated in Postmortem cortical membranes from 9 subjects with Alzheimer's disease (AD) and 9 matched-controls by using [H-3]idazoxan (0.6-30 nM) in the presence of 10(-6) M (-)-adrenaline to prevent binding to alpha2-adrenoceptors. In AD the density (B(max)) of I2-imidazoline sites was significantly higher (+63%) than in controls whereas no differences were apparent in affinity values (K(d)). The results support the hypothesis that the I2 imidazoline site has a major location on glial (astrocyte) cells.

引用

页码：109 / 112

页数：4

共 31 条

[1] INCREASED BINDING OF H-3 L-DEPRENYL IN SPINAL-CORDS FROM PATIENTS WITH AMYOTROPHIC-LATERAL-SCLEROSIS AS DEMONSTRATED BY AUTORADIOGRAPHY [J].