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[31]
YOUDIM MBH, 1990, J NEUR TR S, P239
NON-ADRENOCEPTOR [H-3] IDAZOXAN BINDING-SITES (I2-IMIDAZOLINE SITES) ARE INCREASED IN POSTMORTEM BRAIN FROM PATIENTS WITH ALZHEIMERS-DISEASE
被引：78
作者：
RUIZ, J
MARTIN, I
CALLADO, LF
MEANA, JJ
BARTUREN, F
GARCIASEVILLA, JA
机构：
[1] UNIV BASQUE COUNTRY, DEPT FARMACOL, EUSKAL HERRIKO UNIBERTSITATEA, E-48940 LEIOA, SPAIN
[2] UNIV BALEARIC ISL, DEPT FUNDAMENTAL BIOL & HLTH SCI, NEUROPHARMACOL LAB, PALMA DE MALLORCA, SPAIN
关键词：
I2-IMIDAZOLINE SITE;
IMIDAZOLINE PREFERRING RECEPTORS;
H-3]IDAZOXAN;
ALZHEIMERS DISEASE;
HUMAN BRAIN;
GLIA;
PI(2)-ADRENOCEPTORS;
D O I：
10.1016/0304-3940(93)90925-B
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The 12-imidazoline site (a non-adrenergic mitochondrial site for which a glial location has been proposed and that is associated with the B-form of the enzyme monoamine oxidase) was evaluated in Postmortem cortical membranes from 9 subjects with Alzheimer's disease (AD) and 9 matched-controls by using [H-3]idazoxan (0.6-30 nM) in the presence of 10(-6) M (-)-adrenaline to prevent binding to alpha2-adrenoceptors. In AD the density (B(max)) of I2-imidazoline sites was significantly higher (+63%) than in controls whereas no differences were apparent in affinity values (K(d)). The results support the hypothesis that the I2 imidazoline site has a major location on glial (astrocyte) cells.
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页码：109 / 112
页数：4
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