AN EXTREMELY POTENT INHIBITOR FOR BETA-GALACTOSIDASE

被引：91

作者：

ICHIKAWA, Y

IGARASHI, Y

机构：

[1] Department of Pharmacology, Molecular Sciences The Johns Hopkins University School of Medicine, Baltimore

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 26期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(95)00870-I

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new galactose-type iminosugar in which a nitrogen atom is in the anomeric position was synthesized and was found to be an extremely potent inhibitor for beta-galactosidase with Ki = 4 nM.

引用

页码：4585 / 4586

页数：2

共 9 条

[1] FACILE SYNTHESIS OF A NEW-TYPE OF IMINOSUGAR - A NITROGEN ATOM IS IN THE ANOMERIC POSITION
ICHIKAWA, M
ICHIKAWA, Y
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 1995, 3 (02) : 161 - 165
[2] IGARASHI Y, 1995, IN PRESS TETRAHEDRON
[3] PEPTIDES .6. SOME OXIME CARBONATES AS NOVEL TERT-BUTOXYCARBONYLATING REAGENTS
ITOH, M
HAGIWARA, D
KAMIYA, T
[J]. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1977, 50 (03) : 718 - 721
[4] ISOFAGOMINE, A POTENT, NEW GLYCOSIDASE INHIBITOR
JESPERSEN, TM
DONG, WL
SIERKS, MR
SKRYDSTRUP, T
LUNDT, I
BOLS, M
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1994, 33 (17): : 1778 - 1779
[5] ENZYME-CATALYZED ALDOL CONDENSATION FOR ASYMMETRIC-SYNTHESIS OF AZASUGARS - SYNTHESIS, EVALUATION, AND MODELING OF GLYCOSIDASE INHIBITORS
KAJIMOTO, T
LIU, KKC
PEDERSON, RL
ZHONG, ZY
ICHIKAWA, Y
PORCO, JA
WONG, CH
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (16) : 6187 - 6196
[6] KASKAR B, 1990, SYNTHESIS-STUTTGART, P1031
[7] GLYCOSIDE HYDROLASES - MECHANISTIC INFORMATION FROM STUDIES WITH REVERSIBLE AND IRREVERSIBLE INHIBITORS
LEGLER, G
[J]. ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, 1990, 48 : 319 - 384
[8] ENZYME-CATALYZED ORGANIC-SYNTHESIS - PRACTICAL ROUTES TO AZA SUGARS AND THEIR ANALOGS FOR USE AS GLYCOPROCESSING INHIBITORS
LOOK, GC
FOTSCH, CH
WONG, CH
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1993, 26 (04) : 182 - 190
[9] OXIDATION OF LONG-CHAIN AND RELATED ALCOHOLS TO CARBONYLS BY DIMETHYL-SULFOXIDE ACTIVATED BY OXALYL CHLORIDE
MANCUSO, AJ
HUANG, SL
SWERN, D
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1978, 43 (12) : 2480 - 2482

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