UNCOORDINATE EXPRESSIONS OF TYPE-I AND TYPE-III COLLAGENS, COLLAGENASE AND TISSUE INHIBITOR OF MATRIX METALLOPROTEINASE-1 ALONG IN-VITRO PROLIFERATIVE LIFE-SPAN OF HUMAN SKIN FIBROBLASTS - REGULATION BY ALL-TRANS-RETINOIC ACID

被引：37

作者：

BIZOTFOULON, V

BOUCHARD, B

HORNEBECK, W

DUBERTRET, L

BERTAUX, B

机构：

[1] UNIV PARIS 05,FAC CHIRURT DENT,BIOL TISSU CONJONCT LAB,CNR,URA 1813,F-92120 MONTROUGE,FRANCE

[2] HOP ST LOUIS,INSERM,U312,PHARMACOL CUTANEE LAB,F-75010 PARIS,FRANCE

来源：

CELL BIOLOGY INTERNATIONAL | 1995年 / 19卷 / 02期

关键词：

FIBROBLASTS; AGING; COLLAGENASE; COLLAGENS; TIMP-1 (TISSUE INHIBITOR OF MATRIX METALLOPROTEINASE 1); RETINOIC ACID;

D O I：

10.1006/cbir.1995.1053

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In vitro human skin fibroblasts aging was characterized by a continuous increase of collagenase mRNA levels. On the contrary, TIMP-1 mRNA level decreased only at late passages (> 65 % of proliferative life span). Type I and III mRNA levels showed a high variability depending on cell strains studied. However, type I and III collagen expressions varied parallely. All-trans retinoic acid (RA) decreased collagenase expression and stimulated TIMP-1 expression. Under RA action, high variability in mRNAs levels encoding type I and III collagens was observed with HSF passages. However, RA tended to correct variations in collagens expressions observed along HSF life span.

引用

页码：129 / 135

页数：7

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