CONSERVATION OF A HEXAPEPTIDE SEQUENCE IN THE ANCHOR REGION OF SURFACE-PROTEINS FROM GRAM-POSITIVE COCCI

被引：325

作者：

FISCHETTI, VA

PANCHOLI, V

SCHNEEWIND, O

机构：

[1] The Rocketeller University, New York, New York, 10021

来源：

MOLECULAR MICROBIOLOGY | 1990年 / 4卷 / 09期

关键词：

D O I：

10.1111/j.1365-2958.1990.tb02072.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A highly conserved hexapeptide sequence (both at the protein‐and DNA level) has been identified within the C‐terminal end of all 11 known surface proteins from Gram‐positive cocci. The hexapeptide, with the consensus sequence LPXTGE, is located about 9 amino acids N‐terminal from the C‐terminal hydrophobic domain which is found in all these surface molecules. The conservation of the hexapeptide, despite sequence variation within the regions flanking it, suggests that it is important for the attachment of these proteins within the cell. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：1603 / 1605

页数：3

共 16 条

[11] MOLECULAR CHARACTERIZATION OF A SURFACE PROTEIN ANTIGEN GENE FROM SEROTYPE-C STREPTOCOCCUS-MUTANS, IMPLICATED IN DENTAL-CARIES
OKAHASHI, N
SASAKAWA, C
YOSHIKAWA, M
HAMADA, S
KOGA, T
[J]. MOLECULAR MICROBIOLOGY, 1989, 3 (05) : 673 - 678
[12] STRUCTURE AND EVOLUTION OF THE REPETITIVE GENE ENCODING STREPTOCOCCAL PROTEIN-G
OLSSON, A
ELIASSON, M
GUSS, B
NILSSON, B
HELLMAN, U
LINDBERG, M
UHLEN, M
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1987, 168 (02): : 319 - 324
[13] IDENTIFICATION OF AN ENDOGENOUS MEMBRANE ANCHOR-CLEAVING ENZYME FOR GROUP-A STREPTOCOCCAL M-PROTEIN - ITS IMPLICATION FOR THE ATTACHMENT OF SURFACE-PROTEINS IN GRAM-POSITIVE BACTERIA
PANCHOLI, V
FISCHETTI, VA
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (06) : 2119 - 2133
[14] ISOLATION AND CHARACTERIZATION OF THE CELL-ASSOCIATED REGION OF GROUP-A STREPTOCOCCAL M6 PROTEIN
PANCHOLI, V
FISCHETTI, VA
[J]. JOURNAL OF BACTERIOLOGY, 1988, 170 (06) : 2618 - 2624
[15] SEQUENCE AND STRUCTURAL CHARACTERISTICS OF THE TRYPSIN-RESISTANT T6 SURFACE PROTEIN OF GROUP-A STREPTOCOCCI
SCHNEEWIND, O
JONES, KF
FISCHETTI, VA
[J]. JOURNAL OF BACTERIOLOGY, 1990, 172 (06) : 3310 - 3317
[16] NUCLEOTIDE-SEQUENCE OF THE GENE FOR A FIBRONECTIN-BINDING PROTEIN FROM STAPHYLOCOCCUS-AUREUS - USE OF THIS PEPTIDE SEQUENCE IN THE SYNTHESIS OF BIOLOGICALLY-ACTIVE PEPTIDES
SIGNAS, C
RAUCCI, G
JONSSON, K
LINDGREN, PE
ANANTHARAMAIAH, GM
HOOK, M
LINDBERG, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (02) : 699 - 703

← 1 2 →