A NOVEL SYNTHESIS OF NOR-C-STATINE

被引：16

作者：

DUGGER, RW

RALBOVSKY, JL

BRYANT, D

COMMANDER, J

MASSETT, SS

SAGE, NA

SELVIDIO, JR

机构：

[1] Pfizer Central Research Process Research and Development Department Eastern Point Road Groton

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(00)61770-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthesis of nor-C-statine is described. Benzylation of a malate dianion, differentiation of the two carboxylates and a Hofmann degradation of one of the carboxylates constitute the key steps of the synthesis.

引用

页码：6763 / 6766

页数：4

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