PREDNISOLONE ENHANCES MYOGENESIS AND DYSTROPHIN-RELATED PROTEIN IN SKELETAL-MUSCLE CELL-CULTURES FROM MDX MOUSE

被引：49

作者：

PASSAQUIN, AC

METZINGER, L

LEGER, JJ

WARTER, JM

POINDRON, P

机构：

[1] UNIV LOUIS PASTEUR,DEPT IMMUNOL IMMUNOPHARMACOL & PATHOL,BIOL MUSCLE LAB,BP24,F-67401 ILLKIRCH GRAFFENS,FRANCE

[2] UNIV STRASBOURG 1,HOSPICES CIVILS,DEPT IMMUNOL IMMUNOPHARMACOL & PATHOL,F-67070 STRASBOURG,FRANCE

[3] FAC PHARM MONTPELLIER,INSERM,U300,F-34060 MONTPELLIER,FRANCE

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1993年 / 35卷 / 04期

关键词：

ACETYLCHOLINE RECEPTORS; DYSTROPHIN; DUCHENNE MUSCULAR DYSTROPHY; GLUCOCORTICOIDS; SKELETAL MUSCLE CULTURES;

D O I：

10.1002/jnr.490350403

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The differentiation of skeletal muscle cells from mdx mice which lack dystrophin expression was examined after glucocorticoid treatment, namely alpha-methylprednisolone (PDN). Primary skeletal muscle cell cultures were established from newborn mdx, congenic C57BL/10, and allogenic BALB/C mice. We show that PDN promotes the myogenesis of both mdx- and control mice-derived cultures as determined by 1) the number of myotubes, 2) acetylcholine receptors, and 3) dystrophin and dystrophin-related protein levels. These results support the hypothesis that PDN could enhance the myogenesis of satellite cells and increase dystrophin-related protein expression in DMD treated patients.

引用

页码：363 / 372

页数：10

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