CHIRAL PHOSPHORUS LIGANDS FOR THE ASYMMETRIC CONJUGATE ADDITION OF ORGANOCOPPER REAGENTS

被引：153

作者：

ALEXAKIS, A

FRUTOS, J

MANGENEY, P

机构：

[1] Laboratoire de Chimie des Organo-Elements, CNRS UA 473 Université P. et M. Curie, F-75252 Paris Cedex 05, 4, Place Jussieu

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 12期

关键词：

D O I：

10.1016/S0957-4166(00)82216-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The asymmetric conjugate addition of medium order alkyl cuprate reagents, R(5)Cu(3)Li(2), to 2-cyclohexen-1-one, 2-cyclopenten-1-one and 2-cyclohepten-1-one, with the help of phosphorus ligand B*, is described. 3-Alkyl substituted cyclohexanones are obtained in essentially optically pure form. The same chiral ligand, associated with CuI, in catalytic amount (10%), allows the asymmetric conjugate addition of Et(2)Zn to 2-cyclohexen-1-one.

引用

页码：2427 / 2430

页数：4

共 8 条

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