CARDIOVASCULAR ACTIONS OF ADENOSINES, BUT NOT ADENOSINE RECEPTORS, DIFFER IN RAT AND GUINEA-PIG

被引：26

作者：

UEEDA, M

THOMPSON, RD

PADGETT, WL

SECUNDA, S

DALY, JW

OLSSON, RA

机构：

[1] UNIV S FLORIDA,BIOCHEM & MOLEC BIOL,TAMPA,FL 33612

[2] NATL INST DIABET & DIGEST & KIDNEY,BIOORGAN CHEM LAB,BETHESDA,MD 20892

来源：

LIFE SCIENCES | 1991年 / 49卷 / 18期

关键词：

D O I：

10.1016/0024-3205(91)90199-L

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This study compared the structure-activity relationships of 16 analogues at the A1 and A2 adenosine receptors (A1AR, A2AR) of rat and guinea pig. Radioligand binding studies revealed no marked differences in the affinities of each analogue at the A1AR of brain cortex or the A2AR of brain striatum. Bioassay employing Langendorff heart preparations showed that the guinea pig is more sensitive than the rat to A1AR-mediated slowing of conduction through the atrioventricular node and, in some instances, to A2AR-mediated coronary vasodilation. That difference could reflect factors such as receptor density or efficacy of coupling to effector systems.

引用

页码：1351 / 1358

页数：8

共 13 条

[1]

BRUNS RF, 1986, MOL PHARMACOL, V29, P331

[2]

CHENG Y, 1973, BIOCHEM PHARMACOL, V22, P3099

[3] EFFECT OF ADENOSINE ON ATRIOVENTRICULAR-CONDUCTION .1. SITE AND CHARACTERIZATION OF ADENOSINE ACTION IN THE GUINEA-PIG ATRIOVENTRICULAR NODE [J].