ENANTIOSPECIFIC AND DIASTEREOSELECTIVE SYNTHESIS OF CIS MONOBACTAMS THROUGH ELECTROPHILIC AMINATION OF CHIRAL 3-HYDROXYESTERS

被引：12

作者：

BANFI, L

CASCIO, G

GUANTI, G

MANGHISI, E

NARISANO, E

RIVA, R

机构：

[1] IST CHIM ORGAN,I-16132 GENOA,ITALY

[2] CNR,CTR STUDIO CHIM COMPOSTI CICLOALIFAT AROMAT,I-16132 GENOA,ITALY

[3] LUSO FARMACO SPA,I-20132 MILAN,ITALY

来源：

TETRAHEDRON | 1994年 / 50卷 / 41期

关键词：

D O I：

10.1016/S0040-4020(01)89308-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new efficient entry into cis monobactams starting from beta-hydroxyesters is reported. This preparation is based on the stereoselective ''electrophilic amination'' of beta-hydroxyester dianions and on Miller's biomimetic synthesis of the beta-lactam nucleus. By this route, key intermediates for the preparation of pharmacologically important cis aztreonam 2 and carumonam 3 were prepared.

引用

页码：11967 / 11982

页数：16

共 80 条

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